FAT LOSSSAFETY CONCERN
Yohimbine
Alpha-2 antagonist with a real fat-loss mechanism and a real cardiovascular risk profile.
EFFECTIVE DOSE
Studied at 0.2 mg/kg fasted — but risk/benefit is poor for most
HOW IT WORKS
Blocks alpha-2 adrenergic receptors, which normally suppress lipolysis in stubborn fat.
WHAT THE EVIDENCE SUPPORTS
- Some evidence for fasted fat loss in already-lean individuals
WHAT TO LOOK OUT FOR
- Dosing in commercial products is wildly inconsistent (studies have found 20%–150% of label claims).
- Do not stack with caffeine, synephrine, or high-stimulant pre-workouts.
- Contraindicated with SSRIs, MAOIs, and anxiety disorders.
SIDE EFFECTS
- Anxiety, panic attacks, hypertension, tachycardia
- Serious interactions with common medications
SOURCES
Reviewed 11/1/2025 · Brawn Supplement Reviewer
Educational content. Not medical advice. Talk to a licensed professional before starting any supplement, especially if you take medications or have a medical condition.